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/F5 1 Tf
.7084 0 TD
[(mi)19.5(ce)18.5(,)-458.4(r)0(e)19.7(s)0(u)21(l)0(t)20.6(i)0(n)20.7(g)-461.9(in)-445.8(re)19.7(-)]TJ
-15.4591 -1.1116 TD
-.0203 Tc
[(d)-20.3(u)-5.2(c)-20.3(e)-1.8(d)-384.3(c)-20.3(ar)-20.3(di)-20.3(ot)-20.3(ox)-20.3(ic)-20.3(i)-6.5(t)-20.3(y)-374(\()-20.3(34)-20.3(\).)-386.6(I)-20.3(t)-373.9(h)-20.3(a)-.6(s)-384.1(a)-20.3(ls)-20.3(o)-373.6(b)-20.3(ee)-20.3(n)-375(r)-20.3(ep)-20.3(o)-5.2(r)-20.3(te)-20.3(d)-375(t)-20.3(ha)-20.3(t)-375.1(t)-20.3(he)]TJ
T*
0 Tc
[(ac)18.5(ti)14.8(vi)20.7(ty)-284.6(of)-284.4(CB)18.8(R1)-285.5(is)-284.4(re)19.7(la)19.6(ti)20.6(ve)19.7(ly)-284.6(hi)15(gh)-284.4(in)-278.8(hu)15.1(ma)18.4(n)-289.1(b)0(r)15.1(e)0(a)18.5(s)0(t)-284.4(a)0(n)19.7(d)-294.8(lu)20.7(ng)]TJ
0 -1.1174 TD
[(ca)18.5(nc)13.9(er)-216.4(pa)19.7(ti)20.6(en)19.7(t)-225.9(t)0(i)20.6(s)0(s)15.5(u)0(e)19.7(s)-225.5(wh)20(en)-216.5(co)19.7(mp)19.6(ar)19.7(ed)-216.5(to)-215.4(no)20.8(rm)19.6(al)-216.6(su)15.3(bj)20.7(ec)18.5(ts)-215.2(\(2)20.9(4\))15.1(.)]TJ
1.0137 -1.1116 TD
[(In)-232.6(th)20.7(is)-209.5(st)20.9(ud)15.1(y,)-206.1(ph)20.8(ar)14(ma)18.4(co)19.7(lo)20.7(gi)20.7(ca)18.5(l)-220.1(i)0(n)20.7(h)0(i)14.9(b)0(i)20.7(t)0(i)20.6(o)0(n)-209.5(o)0(f)-209.5(C)0(B)18.8(R)0(1)-210.6(i)0(s)-215.2(s)0(h)21(o)0(w)20(n)]TJ
-1.0137 -1.1116 TD
[(to)-353.7(en)19.7(ha)19.7(nc)19.7(e)-365.1(t)0(h)20.7(e)-359.4(ch)13.9(em)24.2(ot)15(he)19.7(ra)19.7(pe)19.7(ut)20.7(ic)-354.8(ef)19.7(c)19.8(ac)18.5(y)-364(o)0(f)-347.7(D)0(O)13.3(X)-359.1(in)-353.7(br)20.9(ea)18.5(st)]TJ
0 -1.1174 TD
[(ca)18.5(nc)13.9(er)19.7(s)-294.6(a)0(n)19.7(d)-300.6(si)20.9(mu)19.6(lt)20.6(an)13.9(eo)19.7(us)21(ly)-284.6(am)18.5(el)13.8(io)20.7(ra)19.7(te)-285.7(ca)12.8(rd)20.9(io)20.7(to)20.7(xi)20.7(ci)19.6(ty)15(.)-297.2(T)0(h)19.6(e)0(r)19.7(e)0(-)]TJ
0 -1.1116 TD
[(fo)15.1(re)19.7(,)-279.9(w)0(e)-269.2(p)0(r)15.1(o)0(p)20.8(o)0(s)21(e)-284.5(th)20.7(at)-268.4(CB)18.8(R1)-273.9(is)-272.8(a)-278.7(v)0(a)19.7(l)0(u)20.7(a)0(b)19.7(l)0(e)-274.2(t)0(a)19.6(r)0(g)20.9(e)0(t)-274.2(m)0(o)19.6(l)0(e)19.6(c)0(u)19.7(l)0(e)-274.2(f)0(o)20.9(r)]TJ
T*
[(fu)15.1(tu)20.7(re)-262.5(dr)20.9(ug)-261.4(de)19.7(ve)19.7(lo)20.7(pm)19.6(en)19.7(t)-271.9(i)0(n)-261.5(p)0(a)19.7(t)0(i)20.6(e)0(n)19.7(t)0(s)-261.3(w)0(i)19.8(t)0(h)-261.5(b)0(r)20.9(e)0(a)18.5(s)0(t)-261.3(c)0(a)18.5(n)0(c)13.9(e)0(r)19.7(.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 297.7511 Tm
(Results)Tj
/F12 1 Tf
0 -1.8336 TD
[(Combined)-339.7(treatment)-329.2(with)-336.5(the)-334.8(specic)-332.7(inhibitor)]TJ
0 -1.2203 TD
[(of)-336.7(CBR1)-336.7(\(OH-PP-Me\))-332.3(and)-335.7(DOX)-332.6(enhances)-335.4(the)]TJ
0 -1.2266 TD
[(chemotherapeutic)-305.8(effect)-303.5(of)-305.1(DOX)-300.9(in)-304.9(breast)-302.9(cancer)-305.3(cells)]TJ
/F5 1 Tf
9.843 0 0 9.843 69.7323 242.929 Tm
[(To)-544.8(determine)-544.8(whether)-546.7(CBR1)-548.9(inhibition)-541.6(enhanced)-549.1(cell)]TJ
-1.0137 -1.1116 TD
[(de)13.9(at)19.5(h)-531(d)0(u)20.8(r)0(i)20.7(n)0(g)-520.6(D)0(O)13.3(X)-531.9(tr)20.7(ea)18.5(tm)19.5(en)19.7(t,)-523(we)-522.6(ut)20.7(il)20.6(iz)13.8(ed)-521.7(MD)19.1(A-)20(MB)18.9(-1)20.9(57)20.8(,)]TJ
T*
[(MD)19.1(A-)14.2(MB)18.9(-4)20.9(36)20.8(,)-372.1(M)0(C)18.9(F)0(-)15.3(7)0(,)-361.6(a)0(n)19.7(d)-375.5(MC)18.9(F1)21(0A)-365.9(ce)18.5(ll)-365.3(li)20.6(ne)19.7(s,)-367.2(wh)20(ic)19.6(h)-375.5(a)0(r)19.7(e)]TJ
0 -1.1174 TD
-.0215 Tc
[(t)-5.4(r).5(ip)-5.3(le-)-5.3(n).4(eg)-5.3(ativ)-5.3(e/b)-5.3(a)-.7(sa)-6.5(l-B)-190.7(m)-.8(amm)-6.5(a)]TJ
12.0723 0 TD
-.0202 Tc
[(ry)-188.3(carcinoma,)-184.9(E)-5.2(R-positive/PgR-)]TJ
-12.0723 -1.1116 TD
0 Tc
[(po)15.1(si)20.9(ti)20.6(ve)-251(lu)20.7(mi)19.5(na)19.7(l)-260.4(m)0(a)18.4(m)0(m)18.4(a)0(r)19.7(y)-260.3(ca)18.5(rc)19.7(in)20.7(om)19.6(a,)-253.4(an)19.7(d)-260.3(n)0(o)20.8(r)0(m)19.6(a)0(l)-251.2(b)0(r)20.9(e)0(a)18.5(s)0(t)-249.8(c)0(e)18.5(l)0(l)]TJ
T*
[(li)14.8(ne)19.7(s,)-188.6(re)19.7(sp)21(ec)18.5(ti)20.6(ve)19.7(ly)15(.)-199.3(M)0(D)19.1(A)0(-)20(M)0(B)18.9(-)0(1)20.9(5)0(7)20.8(,)-199.3(MD)19.1(A-)20(MB)18.9(-4)20.9(36)15.1(,)-193.5(a)0(n)13.9(d)-196.9(MC)18.9(F-)]TJ
T*
[(7)-398.5(c)0(e)18.5(l)0(l)14.8(s)-398.3(ha)19.7(ve)-389.3(hi)20.7(gh)20.8(er)-389.2(CB)18.8(R1)-389.1(ex)19.7(pr)20.9(es)19.9(si)20.9(on)-388.1(le)13.8(ve)19.7(ls)-388(th)20.7(an)-389.3(MC)18.9(F1)21(0A)]TJ
0 -1.1174 TD
[(\(S)15.3(up)20.8(pl)20.7(em)18.5(en)19.7(ta)19.6(ry)-301.7(Fi)20.9(g.)-298.3(S1)21(A;)-302.7(Su)21(pp)20.8(le)19.6(me)18.4(nt)14.9(ar)19.7(y)-306.4(D)0(a)18.8(t)0(a)-303(a)0(r)19.7(e)-313.3(av)19.7(ai)19.5(la)19.6(bl)20.7(e)]TJ
0 -1.1116 TD
[(on)15.1(li)20.6(ne)-285.6(at)-285.7(ww)19.1(w.)17.6(li)20.6(eb)19.7(er)19.7(tp)20.7(ub)20.8(.c)17.3(om)19.6(/a)19.6(rs)21.1(\).)-286.7(Al)19.8(l)-295(o)0(f)-284.4(t)0(h)20.7(e)-296(ce)18.5(ll)-290.4(li)20.6(ne)19.7(s)-294.6(w)0(e)18.8(r)0(e)]TJ
T*
[(tr)15(ea)18.5(te)19.6(d)-346.7(w)0(i)14.1(t)0(h)-336.4(2)0(0)-146.2(n)]TJ
/F6 1 Tf
6.7677 0 TD
(M)Tj
/F5 1 Tf
1.1865 0 TD
[(DO)19.1(X.)-339.5(Ef)19.7(fe)19.7(ct)13.8(s)-346.5(o)0(n)-342(c)0(e)18.5(l)0(l)-342.3(s)0(u)21(r)0(v)20.9(i)0(v)20.7(a)0(l)-343.3(w)0(e)18.8(r)0(e)-343.1(a)0(l)19.5(s)0(o)]TJ
-7.9542 -1.1174 TD
[(ob)15.1(se)19.9(rv)20.9(ed)-199.2(in)-198.2(a)-209.6(c)0(o)19.7(m)0(b)19.6(i)0(n)15(e)0(d)-199.2(t)0(r)20.7(e)0(a)18.5(t)0(m)19.5(e)0(n)19.7(t)-208.6(wi)19.8(th)-203.9(8)]TJ
/F13 1 Tf
16.0408 0 TD
(l)Tj
/F6 1 Tf
.5414 0 TD
(M)Tj
/F5 1 Tf
1.0425 0 TD
[(OH)19.1(-P)21(P-)21(Me)18.8(.)-210.8(O)0(H)19.1(-)]TJ
-17.6247 -1.1116 TD
[(PP)15.4(-M)20(e)-290.2(a)0(l)19.5(o)0(n)20.8(e)-296(di)20.7(d)-294.8(n)0(o)20.8(t)-289.2(af)14(fe)19.7(ct)-280(ce)18.5(ll)-284.7(vi)20.7(ab)19.7(il)20.6(it)14.8(y;)-278.8(ho)20.8(we)18.8(ve)19.7(r,)-286.7(co)19.7(mb)19.6(in)20.7(a-)]TJ
T*
[(ti)14.8(on)-347.8(tr)15(ea)18.5(tm)19.5(en)19.7(t)-364.1(o)0(f)-347.7(D)0(O)13.3(X)-359.1(an)19.7(d)-364(O)0(H)19.1(-)0(P)15.3(P)0(-)21(M)0(e)-355.6(i)0(n)20.7(c)0(r)19.7(e)0(a)18.5(s)0(e)19.9(d)-364(ce)18.5(ll)-353.8(de)19.7(at)19.5(h)]TJ
0 -1.1174 TD
[(co)19.7(mp)19.6(ar)14(ed)-348.9(to)-347.9(DO)19.1(X)-359.1(a)0(l)19.5(o)0(n)20.8(e)-359.4(in)-347.9(al)13.8(l)-358.3(c)0(e)18.5(l)0(l)-348(l)0(i)20.6(n)0(e)19.7(s)-358(\(F)15.3(ig)20.7(.)-354.8(1)0(A)-354.4(a)0(n)19.7(d)-358.2(Su)21(p-)]TJ
0 -1.1116 TD
[(pl)14.9(em)24.2(en)13.9(ta)19.6(ry)-261.4(Fi)15.1(g.)-263.7(S1)21(B\))19.8(.)-274.1(H)0(o)14.2(w)0(e)18.8(v)0(e)19.7(r)0(,)-263.7(t)0(h)20.7(e)0(r)19.7(e)-278.7(wa)18.8(s)-277.4(n)0(o)-261.4(s)0(i)15.1(g)0(n)20.8(i)0()20.9(c)0(a)18.5(n)0(t)-267.3(d)0(i)20.7(f)0(-)]TJ
T*
[(fe)14(re)19.7(nc)19.7(e)-209.6(i)0(n)-203.9(M)0(C)18.9(F)0(1)21(0)0(A)-204.7(c)0(e)18.5(l)0(l)-204(v)0(i)20.7(a)0(b)19.7(i)0(l)20.6(i)0(t)14.8(y)-208.4(af)19.7(te)13.8(r)-208.4(t)0(r)20.7(e)0(a)12.8(t)0(m)25.2(e)0(n)13.9(t)-208.6(of)-203.8(DO)19.1(X)-215.1(w)0(i)19.8(t)0(h)]TJ
0 -1.1174 TD
[(or)-192.2(wi)14.1(th)20.7(ou)20.8(t)-202.8(O)0(H)19.1(-)0(P)21(P)0(-)21(M)0(e)18.8(.)-205(Th)19.6(is)-192.2(is)-192.2(pr)20.9(ob)15.1(ab)19.7(ly)-192.4(du)20.8(e)-203.8(t)0(o)-192.4(t)0(h)20.7(e)-203.8(lo)20.7(w)-203.6(l)0(e)19.6(v)0(e)19.7(l)-202.8(of)]TJ
0 -1.1116 TD
[(CB)18.8(R1)-262.4(ex)19.7(pr)20.9(es)14.1(si)20.9(on)-261.4(in)-255.8(th)15(is)-255.6(ce)18.5(ll)-261.6(li)20.6(ne)19.7(.)]TJ
26.5234 67.9184 TD
[(T)15(o)-173.9(co)13.9(n)21(rm)-164.7(th)20.7(e)-175.1(s)0(y)21(n)0(e)19.7(r)0(g)15.1(i)0(s)20.9(t)0(i)20.6(c)-175(ef)19.7(fe)19.7(ct)-164.8(of)-169.2(OH)19.1(-P)21(P-)21(Me)-165.5(an)19.7(d)-173.9(D)0(O)19.1(X)-174.8(on)]TJ
-1.0137 -1.1174 TD
-.0197 Tc
[(t)-19.7(h)1(e)-373.3(c)-19.7(el)-19.7(l)-362(d)-19.7(ea)-19.7(th)-19.7(,)-364.1(w)-19.7(e)-363.8(p)-19.7(er)-19.7(fo)-19.7(rm)-19.7(ed)]TJ
/F6 1 Tf
12.0263 0 TD
0 Tc
[(in)-342.1(vi)13.8(tr)20.9(o)]TJ
/F5 1 Tf
3.3349 0 TD
[(cl)19.5(on)20.8(og)20.8(en)19.7(ic)-343.3(as)14.1(sa)19.9(y.)-338.6(Th)13.9(e)]TJ
-15.3611 -1.1116 TD
[(co)19.7(mb)19.6(in)20.7(at)19.6(io)20.7(n)-225.7(t)0(r)20.7(e)0(a)18.5(t)0(m)19.5(e)0(n)19.7(t)-225.9(ma)18.4(rk)20.9(ed)19.7(ly)-215.4(de)19.7(cr)19.7(ea)18.5(se)19.9(d)-225.7(c)0(o)19.7(l)0(o)20.7(n)0(y)-215.3(f)0(o)20.9(r)0(m)19.7(a)0(t)19.6(i)0(o)20.7(n)0(s)]TJ
T*
[(in)-244.2(MD)19.1(A-)20(MB)13.1(-1)20.9(57)-244.1(an)19.7(d)-260.3(M)0(C)18.9(F)0(-)21(7)-254.5(ce)18.5(ll)20.6(s,)-246.2(co)13.9(mp)19.6(ar)19.7(ed)-245.3(to)-250(do)20.8(xo)20.8(ru)20.9(bi)20.7(ci)19.5(n)]TJ
T*
[(tr)20.7(ea)18.5(tm)19.5(en)19.7(t)-335.3(a)0(l)19.5(o)0(n)20.8(e)-336.3(\(F)21(ig)20.7(.)-331.7(1)0(B)-325.8(a)0(n)19.7(d)-329.4(Su)21(pp)15.1(le)19.5(me)18.5(nt)20.7(ar)19.7(y)-335.2(F)0(i)20.9(g)0(.)-321.3(S)0(1)21(C)0(\))19.8(.)-331.7(Th)13.9(e)]TJ
0 -1.1174 TD
[(ch)19.7(an)19.7(ge)19.7(s)-196.7(i)0(n)-186.6(a)0(p)19.7(o)0(p)20.8(t)0(o)15(s)0(i)20.9(s)0(-)21.1(r)0(e)19.7(l)0(a)13.8(t)0(e)19.6(d)-196.9(pr)20.9(ot)20.7(ei)19.5(ns)-186.3(we)18.8(re)-187.6(al)19.5(so)-192.1(ex)19.7(am)18.4(in)20.7(ed)19.7(.)-193.5(T)0(h)13.9(e)]TJ
0 -1.1116 TD
[(ex)19.7(pr)20.9(es)19.9(si)15.1(on)-439.9(le)19.6(ve)13.9(ls)-439.9(of)-445.7(cl)19.5(ea)18.5(ve)19.7(d)-456.1(P)0(A)20.1(R)0(P)-446.6(a)0(n)19.7(d)-450.3(ca)18.5(sp)15.3(as)19.9(e-)19.7(7)-456.1(a)0(n)19.7(d)-450.4(th)14.9(e)]TJ
T*
[(ex)19.7(pr)20.9(es)19.9(si)15.1(on)-428.4(le)19.5(ve)19.7(l)-444.7(o)0(f)-428.4(B)0(a)18.6(x)-438.8(we)18.8(re)-435.3(al)19.5(l)-439(s)0(i)20.9(g)0(n)15.1(i)0()20.9(c)0(a)18.5(n)0(t)20.7(l)0(y)-428.5(i)0(n)14.9(c)0(r)19.7(e)0(a)18.5(s)0(e)19.9(d)-438.8(in)]TJ
0 -1.1174 TD
[(co)19.7(mb)19.6(in)20.7(at)19.6(io)20.7(n)-364(t)0(r)20.7(e)0(a)18.5(t)0(m)19.5(e)0(n)19.7(t)-358.3(wi)19.8(th)-353.7(DO)19.1(X)-359.1(a)0(n)19.7(d)-358.2(OH)19.1(-P)15.3(P-)21(Me)-349.9(in)-347.9(ca)18.5(nc)19.7(er)]TJ
0 -1.1116 TD
[(ce)18.5(ll)-359.6(li)20.6(ne)19.7(s)-369.5(\()0(F)15.3(i)0(g)20.7(.)-366.3(1C)-360.3(an)19.7(d)-369.7(S)0(u)15.2(p)0(p)20.8(l)0(e)19.5(m)0(e)18.4(n)0(t)20.7(a)0(r)19.7(y)-369.7(Fi)20.9(g.)-361.6(S1)21(D\))14.2(.)-366.3(S)0(i)20.9(n)0(c)19.7(e)-370.9(th)14.9(e)]TJ
T*
[(MC)18.9(F-)21(7)-260.3(c)0(e)18.5(l)0(l)-250.1(l)0(i)20.6(n)0(e)-251(h)0(a)19.7(s)-260.1(a)-261.4(d)0(e)19.7()0(c)19.8(i)0(e)19.5(n)0(c)19.7(y)-260.3(in)-250(ca)18.5(sp)15.3(as)19.9(e-)19.7(3)-260.3(\()0(4)20.9(9)0(\))20.9(,)-262.6(ac)18.5(ti)20.6(va)19.7(ti)20.6(on)]TJ
0 -1.1174 TD
[(of)-261.4(ca)18.5(sp)21(as)19.9(e-)19.7(7)-271.8(w)0(a)18.8(s)-271.6(ob)20.8(se)19.9(rv)15.1(ed)-256.8(in)-261.5(bo)20.8(th)-261.5(ce)18.5(ll)-261.6(li)20.6(ne)19.7(s.)]TJ
1.0137 -1.1116 TD
[(To)-187.7(verify)-192.1(the)-188.9(effect)-194.5(of)-186.5(combination)-194.6(treatment)-193.5(on)-192.3(cell)-191.3(death,)]TJ
-1.0137 -1.1116 TD
[(terminal)-392.9(transferase)-396.6(dUTP)-392.2(nick)-391.6(end-labeling)-391.4(\(TUNEL\))-398.9(as-)]TJ
T*
[(says)-437.2(were)-445.3(performed.)-443(As)-440.6(expected,)-443.2(TUNEL-positive)-442.5(cells)]TJ
0 -1.1174 TD
[(were)-353.2(highly)-346.7(increased)-354.3(in)-353.7(combination)-350.1(treatment)-354.8(with)-351.1(DOX)]TJ
0 -1.1116 TD
[(and)-453.7(OH-PP-Me)-461.5(compared)-457(with)-460.5(DOX)-455.2(alone)-457.2(\(Fig.)-457(1D)-458.1(and)]TJ
T*
[(Supplementary)-214.9(Fig.)-214.1(S1E\).)-216.2(It)-215.4(is)-215.2(well)-214(known)-219.5(that)-213.2(DOX)-219(induces)]TJ
0 -1.1174 TD
[(ROS)-477.3(generation)-481.3(\(22,)-473.2(50\),)-479(and)-476.8(thus,)-474.3(whether)-477.5(combination)]TJ
0 -1.1116 TD
[(treatment)-199.3(affected)-203.6(ROS)-200.9(generation)-199(was)-201(examined.)-201.4(Combined)]TJ
T*
[(treatment)-349.1(of)-347.7(DOX)-351.5(with)-351.1(OH-PP-Me)-352.1(increased)-354.3(ROS)-350.6(genera-)]TJ
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[(tion)-546.1(compared)-549.2(with)-546.9(DOX)-553.1(treatment)-550.6(alone)-549.4(\(Fig.)-543.4(1E)-550.6(and)]TJ
0 -1.1116 TD
[(Supplementary)-606.6(Fig.)-605.7(S2F,)-611.2(G\).)-605.5(Collectively,)-609.3(these)-606.8(results)]TJ
T*
[(demonstrate)-483.4(that)-483.9(CBR1)-485.6(inhibition)-484(during)-484.8(DOX)-484(treatment)]TJ
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[(enhances)-284(cell)-283.5(death)-278.7(in)-284.5(breast)-279.5(cancer)-287.7(cells.)]TJ
/F12 1 Tf
8.9663 0 0 8.9663 310.8472 440.1636 Tm
[(Knockdown)-331.7(of)-336.7(CBR1)-330.4(increases)-337.8(cell)-333(death)]TJ
0 -1.2203 TD
[(after)-334.2(DOX)-332.6(treatment)-335.5(in)-330.2(breast)-334.6(cancer)-336.9(cells)]TJ
/F5 1 Tf
9.843 0 0 9.843 320.8251 412.781 Tm
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[(knockdown)-363.3(of)-365(CBR1)-364.6(were)-364.7(constructed)-367(using)-362.5(two)-367.2(indepen-)]TJ
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[(dent)-213.1(small)-221.1(hairpin)-216.4(RNA)-213.4(\(shCBR1\))-219(clones)-216.2(in)-215.4(both)-217.6(MDA-MB-)]TJ
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[(157)-406.5(and)-407.6(MCF-7)-404.7(cells.)-408.8(CBR1)-410.7(expression)-410.5(was)-408.3(strongly)-406.3(and)]TJ
T*
[(similarly)-306.3(suppressed)-300.7(in)-301.8(two)-303.8(clones)-308.4(of)-301.7(knocked)-303.8(down)-299(cancer)]TJ
0 -1.1174 TD
[(cells,)-328.1(that)-322.6(is,)-328.1(CBR1)-324.3(shRNA)-330.6(#1)-324.7(and)-327(shRNA)-324.9(#2,)-322.4(in)-324.9(both)-327.1(cell)]TJ
0 -1.1116 TD
[(lines)-323.5(\(Fig.)-324.6(2A\).)-324.4(Knockdown)-323.9(of)-324.7(CBR1)-324.3(increased)-325.5(cancer)-328(cell)]TJ
T*
[(death)-198(by)-198(DOX)-201.8(treatment,)-202.7(as)-204.8(shown)-196.3(by)-198(cell)-202.8(viability)-201.8(\(Fig.)-197.8(2B\).)]TJ
0 -1.1174 TD
[(The)-190(expression)-185.8(levels)-193.3(of)-186.5(cleaved)-191(PARP)-190.3(and)-188.8(caspase-7)-192.7(and)-188.8(the)]TJ
0 -1.1116 TD
[(expression)-231.9(level)-238.5(of)-226.8(Bax)-235.9(were)-232.2(higher)-238.3(in)-227(shCBR1)-234.1(transfectants)]TJ
T*
[(than)-414.6(in)-417(cells)-416.8(transfected)-419.9(with)-420.2(the)-413.5(scrambled)-417.7(controls)-418.9(after)]TJ
T*
[(DOX)-328.5(treatment)-331.8(\(Fig.)-330.3(2C\).)-330.3(The)-328.2(increased)-337(cell)-329.5(death)-330.5(was)-333.4(as-)]TJ
0 -1.1174 TD
[(sociated)-317.6(with)-316.6(an)-314.4(increase)-318.6(in)-313.4(ROS)-321.8(\(Fig.)-313(2D)-314.1(and)-315.5(Supplemen-)]TJ
0 -1.1116 TD
[(tary)-241.8(Fig.)-242.9(S2A\))-241.2(in)-244.2(shCBR1)-245.7(transfectants.)-247(Together,)-246.3(these)-243.9(data)]TJ
T*
[(clearly)-541.3(show)-540.7(that)-535.7(knockdown)-541.9(of)-537.8(CBR1)-543.2(enhances)-543.2(DOX-)]TJ
0 -1.1174 TD
[(induced)-280.9(cell)-283.5(death)-284.4(in)-278.8(breast)-285.3(cancer)-281.9(cells.)]TJ
/F12 1 Tf
8.9663 0 0 8.9663 310.8472 226.4315 Tm
[(Overexpression)-332.3(of)-336.7(CBR1)-330.4(protects)-337.6(breast)-334.6(cancer)]TJ
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[(cells)-332.5(against)-333.8(apoptosis)-337.8(during)-332.9(DOX)-332.6(treatment)]TJ
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9.843 0 0 9.843 320.8251 199.0488 Tm
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T*
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T*
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0 -1.1116 TD
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T*
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T*
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T*
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[(CBR1)-335.3(IN)-335.1(BREAST)-338.7(CANCER)-334.4(CHEMOTHERAPY)-31681.2(71)]TJ
ET
endstream
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